Another movement came on the scene in early 1972, in the form of student protests in Antananarivo. A general strike involving the nation's roughly 100,000 secondary-level students focused on three principal issues: ending the cultural cooperation agreements with France; replacing educational programs designed for schools in France and taught by French teachers with programs emphasizing Malagasy life and culture and taught by Malagasy instructors; and increasing access for economically underprivileged youth to secondary-level institutions. By early May, the PSD sought to end the student strike at any cost; on May 12 and 13, the government arrested several hundred student leaders and sent them to Nosy-Lava. Authorities also closed the schools and banned demonstrations.

Mounting economic stagnation--as revealed in scarcities of investment capital, a general decline in living standards, and the failure to meet even modest development goals--further undermined the government's position. Forces unleashed by the growing economic crisis combined with student unrest to create an opposition alliance. Workers, public servants, peasants, and many unemployed urban youth of Antananarivo joined the student strike, which spread to the provinces. Protesters set fire to the town hall and to the offices of a French-language newspaper in the capital.

The turning point occurred on May 13 when the Republican Security Force (Force Républicaine de Sécurité--FRS) opened fire on the rioters; in the ensuing melee between fifteen and forty persons were killed and about 150 injured. Tsiranana declared a state of national emergency and on May 18 dissolved his government, effectively ending the First Republic. He then turned over full power to the National Army under the command of General Gabriel Ramanantsoa, a politically conservative Merina and former career officer in the French army. The National Army had maintained strict political neutrality in the crisis, and its intervention to restore order was welcomed by protesters and opposition elements.