The original Kh-25 entered service with the Soviet Air Force between 1973-5, equipping the Mikoyan-Gurevich MiG-23, MiG-27 and Sukhoi Su-17M. Since then it has been cleared for use on the MiG-21, MiG-29, Sukhoi Su-17/20/22 family, Sukhoi Su-24, Su-25 and Su-27. It can also be carried by attack helicopters such as the Kamov Ka-50.
The Kh-25MP can be fitted to the MiG-23/27, Su-17/22, Su-24 and Su-25.
Soviet war in Afghanistan
Starting in April 1986, Kh-25MLs were used by Soviet Su-25 Frogfoots from the 378th OshAP (Independent Shturmovik Aviation Regiment) to attack Mujahideen cave entrances used as shelters and weapons storage facilities, such as the Djavara base, next to the Pakistani border. Attacks were carried out from up to 4.5 nm (8 km).
Iraqi invasion of Kuwait
During the Iraqi invasion of Kuwait, on August 2, 1990 an Iraqi Air Force Sukhoi Su-22 from the No.109 Squadron (based at as-Shoibiyah AB) fired a single Kh-25MP anti-radar variant against a Kuwaiti MIM-23B I-HAWK SAM site at Bubiyan Island that had earlier downed another Su-22 from the same unit and a MiG-23BN from the 49th Squadron. This forced a radar shutdown on the HAWK. The HAWK battery (which was operated by some American contractors) was later captured by Iraqi special forces and found out to be in automatic mode of operation, after the contractors fled. Iraq also used its Kh-25s during its war with Iran.
Russia intervention in Syria
Russia's air strikes on terrorists in Syria, used the Su-24 jet with KH-25 laser-guided missiles.